Neuropathology: Part 2 – prions and HIV

Learning outcomes:

By the end of this module you should be able to:


  • define what prions are and how they transmit


  • identify the signs and symptoms of prion diseases and be able to describe the different types


  • identify what human immunodeficiency virus (HIV) is and the stages of infection


  • list the specific effects of HIV on cells in the brain


  • describe how HIV-associated neurocognitive disorder is classified


  • identify which investigations are appropriate.

Module introduction

This module covers two very interesting neuropsychiatric conditions: prion diseases and HIV-associated neurocognitive disorder.


We aim to provide you with an overview of the pathophysiology of these conditions and important clinical information.


At the end of each section you can test your knowledge with our recap questions. 

Learning notes

We recommend that you make some notes as you work through this module.


The 'TrOn Notebook' facility can be accessed throughout the module (allowing you to make notes on each page), and these notes will be saved in your personal area 'My TrOn', for future reference. However, you will not be able to print these notes as one single document.


If you would prefer to make your notes in a separate document you may wish to download the 'learning notes' below. This downloadable Word document will allow you to keep a personalised record of your learning, which you can then save and/or print for future reference.


Download the learning notes document for this module


Continue to Section 1


In the first module in this series, Neuropathology: Part 1  – dementia, we covered the following subjects:


  • HIV brain disease


  • prion diseases.
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