Neuropathology: Part 1 – dementia

by Dr Georgina Chan and reviewed by Dr Judy Rubinsztein

 

Learning outcomes:

 

By the end of this module, you should be able to:

 

  • explain the importance of neuropathology in diagnosing the various types of dementias

     

  • describe the different classifications of dementia and be able to list the various types of dementia within each category of these classifications

     

  • describe the typical clinical presentations of Alzheimer’s disease, vascular dementia, Lewy body dementia and frontotemporal dementia and be able to relate these to their various pathologies

     

  • outline both the macroscopic (gross) and microscopic changes in a brain that is affected by Alzheimer’s disease, vascular dementia (certain types), Lewy body dementia and frontotemporal dementia (including Pick’s disease)

     

  • list the main histopathological lesions of the most common dementias and be able to explain their composition and how they are formed

     

  • describe the main histopathological lesions of the most common dementias on haematoxylin and eosin (H&E) slides and which special stains highlight them

     

  • explain the reasoning for why different immunostains (tau, ubiquitin and synuclein) are used for particular histopathological lesions.

 

Start the module

 

In the second module in this series, Neuropathology: Part 2  – prions and HIV, we cover the following further subjects:

 

  • HIV brain disease

     

  • prion diseases.
© 2018 Royal College of Psychiatrists